13 May 2022 The awards recognised exemplary professionalism and service from across private and public health facilities, and community and primary healthcare sectors, during a particularly challenging year. Rebekah Ogilvie, COVID REACH Team, Canberra Health Services, was named Nurse of the
Year 2022, and Melanee McMahon, Maternity, Calvary Bruce Private Hospital, named Midwife of the Year 2022. As well as professional excellence categories, six recipients of the new consumer recognition awards were announced. Nominations were submitted by members of the public to acknowledge outstanding care provided by a nurse or midwife. The awards ceremony marked the end of International Nurses and Midwives Week, which began with
International Day of the Midwife [5th May] and International Nurses Day [12th May]. More information and profiles of the winners. Winners of the 2022 Nurses and Midwives Excellence Awards
2022 Southern Medical Research Conference
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Cardiovascular club I
11:00 AM
Thursday, February 10, 2022
#1 IGF-1 reduces atheroscelrosis by reducing CXCL12
S Sukhanov1
T Yoshida1
Y Higashi1
S Danchuk1
S Shai1
C Bysani2
P Delafontaine1
1Tulane University School of Medicine, New Orleans, LA
2University of Missouri System, Columbia, MO
Purpose of Study
Atherosclerosis is the leading cause of Cardiovascular Disease, which is still the global leader of mortality. Insulin Like Growth Factor I [IGF1] has been shown to reduce cardiovascular events. IGF1 administration in ApoE deficient [Apoe-/-] mice fed a high fat diet reduced atherosclerosis and reduced plaque macrophages. Results of our previous in vitro experiments suggest that macrophages play a predominant role in mediating IGF1 effects in atherosclerotic plaque, but exact mechanisms remain unclear. We hypothesized that increasing IGF1 levels strictly in macrophages will prevent atherosclerosis.
Methods Used
After breeding a novel macrophage-specific IGF1 overexpressing transgenic mouse to an Apoe-/- background [MF-IGF1 mice], we assessed atherosclerotic plaque burden, stability, and monocyte recruitment. We accelerated atherosclerotic development by feeding animal a high fat diet for three months. We also assessed cholesterol efflux and foam cell formation in vivo and in vitro.
Summary of Results
Macrophage IGF1 overexpression downregulated plaque burden by 30%, reduced plaque macrophages by 47%, and promoted features of a stable plaque phenotype. Monocyte recruitment was reduced by 70% in MF-IGF1 mice and was associated with a 27% reduction in circulating levels of CXC Chemokine Ligand 12 [CXCL12]. CXCL12 protein levels were reduced in plaque and peritoneal macrophages in MF-IGF1 mice. IGF1 completely blocked oxidized low-density lipoprotein [oxLDL]-dependent increase of CXCL12 mRNA transcription [98% reduction, P