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-predictable based on their inhibition of the fight-or-flight response.
- At low doses, the beta blockers are well tolerated, and serious adverse effects are uncommon.
- As the dosage is increased, beta blockers will slow the heart rate and cause bronchoconstriction; therefore, they should be used with caution in patients with asthma or HF.
-Many patients report fatigue and activity intolerance at higher doses because the reduction in heart rate causes the heart to become less responsive to exertion.
-Less common, though sometimes a major cause of poor adherence, is the effect of beta blockers on male sexual function.
-These medications can cause decreased libido and erectile dysfunction [impotence].
-Because abrupt cessation of beta-blocker therapy can result in rebound HTN, angina, and MI, drug doses should be tapered over several weeks.